Platelet-activating factor receptor

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.[5][6]

PTAFR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 GeneCards: PTAFR
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,147,166 bp[1] End 28,193,936 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 65.56 cM Start 132,564,067 bp[2] End 132,582,683 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • G-protein coupled purinergic nucleotide receptor activity • lipopolysaccharide binding • signal transducer activity • mitogen-activated protein kinase binding • platelet activating factor receptor activity • phospholipid binding • lipopolysaccharide receptor activity • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell membrane • secretory granule membrane • tertiary granule membrane Biological process • G-protein coupled receptor signaling pathway • positive regulation of leukocyte tethering or rolling • inositol trisphosphate biosynthetic process • positive regulation of voltage-gated chloride channel activity • positive regulation of phospholipase C activity • negative regulation of blood pressure • interferon-gamma-mediated signaling pathway • positive regulation of inositol phosphate biosynthetic process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcytosis • cytokine production • response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • response to symbiotic bacterium • transcytosis • positive regulation of translation • cellular response to gravity • response to dexamethasone • positive regulation of cellular extravasation • positive regulation of maternal process involved in parturition • chemotaxis • cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine • positive regulation of sensory perception of pain • response to lipopolysaccharide • cellular response to fatty acid • response to organophosphorus • birth • positive regulation of vasoconstriction • immune response • positive regulation of gastro-intestinal system smooth muscle contraction • positive regulation of tumor necrosis factor production • inflammatory response • positive regulation of smooth muscle contraction • positive regulation of neutrophil degranulation • positive regulation of leukocyte cell-cell adhesion • phosphatidylinositol-mediated signaling • lipopolysaccharide-mediated signaling pathway • cellular response to cAMP • signal transduction • positive regulation of smooth muscle cell proliferation • G-protein coupled purinergic nucleotide receptor signaling pathway • neutrophil degranulation • positive regulation of blood vessel diameter • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5724	19204
Ensembl	ENSG00000169403	ENSMUSG00000056529
UniProt	P25105	Q62035
RefSeq (mRNA)	NM_001164723 NM_000952 NM_001164721 NM_001164722	NM_001081211
RefSeq (protein)	NP_000943 NP_001158193 NP_001158194 NP_001158195	NP_001074680
Location (UCSC)	Chr 1: 28.15 – 28.19 Mb	Chr 4: 132.56 – 132.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.[8]