PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[5][6]

PAG1
Identifiers
AliasesPAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDsOMIM: 605767 MGI: 2443160 HomoloGene: 10198 GeneCards: PAG1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.13Start80,967,810 bp[1]
End81,112,068 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55824

94212

Ensembl

ENSG00000076641

ENSMUSG00000027508

UniProt

Q9NWQ8

Q3U1F9

RefSeq (mRNA)

NM_018440

NM_001195031
NM_053182

RefSeq (protein)

NP_060910

NP_001181960
NP_444412

Location (UCSC)Chr 8: 80.97 – 81.11 MbChr 3: 9.69 – 9.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[6]

Interactions

PAG1 has been shown to interact with FYN,[5] C-src tyrosine kinase,[5] Sodium-hydrogen antiporter 3 regulator 1[7] and Abl gene.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000076641 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027508 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". The Journal of Experimental Medicine. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
  6. "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
  7. Brdicková N, Brdicka T, Andera L, Spicka J, Angelisová P, Milgram SL, Horejsí V (October 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Letters. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085. S2CID 12676563.
  8. Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes & Development. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.

Further reading


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