PARD6B

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[5][6]

PARD6B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARD6B, PAR6B, par-6 family cell polarity regulator beta
External IDsOMIM: 608975 MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.13Start50,731,580 bp[1]
End50,756,795 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84612

58220

Ensembl

ENSG00000124171

ENSMUSG00000044641

UniProt

Q9BYG5

Q9JK83

RefSeq (mRNA)

NM_032521

NM_021409

RefSeq (protein)

NP_115910

NP_067384

Location (UCSC)Chr 20: 50.73 – 50.76 MbChr 2: 168.08 – 168.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[6]

Interactions

PARD6B has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
  6. "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)".
  7. Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
  8. Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.