PCGF6

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.[5][6]

PCGF6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCGF6, MBLR, RNF134, polycomb group ring finger 6
External IDsOMIM: 607816 MGI: 1918291 HomoloGene: 12378 GeneCards: PCGF6
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.33Start103,302,796 bp[1]
End103,351,144 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84108

71041

Ensembl

ENSG00000156374

ENSMUSG00000025050

UniProt

Q9BYE7

Q99NA9

RefSeq (mRNA)

NM_001011663
NM_032154

NM_027654
NM_001360632

RefSeq (protein)

NP_001011663
NP_115530

NP_081930
NP_001347561

Location (UCSC)Chr 10: 103.3 – 103.35 MbChr 19: 47.03 – 47.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000156374 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025050 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. hdl:2027.42/72663. PMID 12167161. S2CID 23060582.
  6. "Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading


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