PCK1

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.[5][6]

PCK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
External IDsOMIM: 614168 MGI: 97501 HomoloGene: 1944 GeneCards: PCK1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.31Start57,561,080 bp[1]
End57,568,121 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5105

18534

Ensembl

ENSG00000124253

ENSMUSG00000027513

UniProt

P35558

Q9Z2V4

RefSeq (mRNA)

NM_002591

NM_011044

RefSeq (protein)

NP_002582

NP_035174

Location (UCSC)Chr 20: 57.56 – 57.57 MbChr 2: 173.15 – 173.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See also

  • PEPCK

References

  1. GRCh38: Ensembl release 89: ENSG00000124253 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027513 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".
  6. Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743. S2CID 23586336.

Further reading


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