PLAGL1

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[5][6][7]

PLAGL1
Identifiers
AliasesPLAGL1, LOT1, ZAC, ZAC1, PLAG1 like zinc finger 1
External IDsOMIM: 603044 MGI: 1100874 HomoloGene: 31401 GeneCards: PLAGL1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q24.2Start143,940,300 bp[1]
End144,064,599 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5325

22634

Ensembl

ENSG00000118495

ENSMUSG00000019817

UniProt

Q9UM63

n/a

RefSeq (mRNA)

NM_009538

RefSeq (protein)

n/a

Location (UCSC)Chr 6: 143.94 – 144.06 MbChr 10: 13.06 – 13.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[7]

Interactions

PLAGL1 has been shown to interact with P53.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000118495 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
  6. Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. Bibcode:1998PNAS...95.8835V. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
  7. "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
  8. Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.

Further reading


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