POLE3

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[4][5][6]

POLE3
Identifiers
AliasesPOLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDsOMIM: 607267 MGI: 1933378 HomoloGene: 9694 GeneCards: POLE3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q32Start113,407,235 bp[1]
End113,410,675 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54107

59001

Ensembl

ENSG00000148229

ENSMUSG00000028394

UniProt

Q9NRF9

Q9JKP7

RefSeq (mRNA)

NM_001278255
NM_017443

NM_021498

RefSeq (protein)

NP_001265184
NP_059139

NP_067473

Location (UCSC)Chr 9: 113.41 – 113.41 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][6]

Interactions

POLE3 has been shown to interact with SMARCA5.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000148229 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
  5. Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
  6. "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Further reading


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