POLR3C

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[5][6][7]

POLR3C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82
External IDsOMIM: 617454 MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.1Start145,824,088 bp[1]
End145,844,402 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10623

74414

Ensembl

ENSG00000186141

ENSMUSG00000028099

UniProt

Q9BUI4

Q9D483

RefSeq (mRNA)

NM_001303456
NM_006468

NM_028925

RefSeq (protein)

NP_001290385
NP_006459

NP_083201

Location (UCSC)Chr 1: 145.82 – 145.84 MbChr 3: 96.71 – 96.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

POLR3C has been shown to interact with GTF3C4.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000186141 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028099 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
  6. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
  7. "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
  8. Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  9. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  10. Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". American Journal of Human Genetics. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading


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