POU2AF1

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[5][6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,[9] as exemplified in studies which use BAB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.[10]

POU2AF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDsOMIM: 601206 MGI: 105086 HomoloGene: 4543 GeneCards: POU2AF1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q23.1Start111,352,255 bp[1]
End111,455,630 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5450

18985

Ensembl

ENSG00000110777

ENSMUSG00000032053

UniProt

Q16633

Q64693

RefSeq (mRNA)

NM_006235

NM_011136

RefSeq (protein)

NP_006226

NP_035266

Location (UCSC)Chr 11: 111.35 – 111.46 MbChr 9: 51.21 – 51.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

POU2AF1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000110777 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032053 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.
  6. "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".
  7. https://www.ncbi.nlm.nih.gov/gene?term=(ocab[gene])%20AND%20(Homo%20sapiens[orgn])%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight
  8. Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.
  9. Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.
  10. Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402.
  11. Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
  12. Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
  13. Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
  14. Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.
  15. Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH (March 2017). "TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1". Blood. 129 (10): 1284–1295. doi:10.1182/blood-2016-09-737536. PMID 28053195.

Further reading


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