PPM1D

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.[5][6]

PPM1D
Identifiers
AliasesPPM1D, PP2C-DELTA, WIP1, protein phosphatase, Mg2+/Mn2+ dependent 1D, IDDGIP, JDVS
External IDsOMIM: 605100 MGI: 1858214 HomoloGene: 31185 GeneCards: PPM1D
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q23.2Start60,600,183 bp[1]
End60,666,280 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8493

53892

Ensembl

ENSG00000170836

ENSMUSG00000020525

UniProt

O15297

Q9QZ67

RefSeq (mRNA)

NM_003620

NM_016910

RefSeq (protein)

NP_003611

NP_058606

Location (UCSC)Chr 17: 60.6 – 60.67 MbChr 11: 85.31 – 85.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.[6]

Interactions

PPM1D has been shown to interact with CDC5L.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000170836 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020525 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E (July 1997). "Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner". Proc Natl Acad Sci U S A. 94 (12): 6048–53. Bibcode:1997PNAS...94.6048F. doi:10.1073/pnas.94.12.6048. PMC 20998. PMID 9177166.
  6. "Entrez Gene: PPM1D protein phosphatase 1D magnesium-dependent, delta isoform".
  7. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

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