PRIMA1

Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[5][6]

PRIMA1
Identifiers
AliasesPRIMA1, PRIMA, proline rich membrane anchor 1
External IDsOMIM: 613851 MGI: 1926097 HomoloGene: 15783 GeneCards: PRIMA1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.12Start93,718,298 bp[1]
End93,788,485 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

145270

170952

Ensembl

ENSG00000175785
ENSG00000274089

ENSMUSG00000041669

UniProt

Q86XR5

Q810F0

RefSeq (mRNA)

NM_178004
NM_178013

NM_133364
NM_178023

RefSeq (protein)

NP_821092
NP_821092.1

NP_579942

Location (UCSC)Chr 14: 93.72 – 93.79 MbChr 12: 103.2 – 103.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[5] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[7] The PRAD interacts with the C-terminal T-peptide of AChE.[8]

PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[6] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.

Clinical significance

The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[9]

References
  1. ENSG00000274089 GRCh38: Ensembl release 89: ENSG00000175785, ENSG00000274089 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041669 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: proline rich membrane anchor 1".
  6. Perrier AL, Massoulié J, Krejci E (Jan 2002). "PRiMA: the membrane anchor of acetylcholinesterase in the brain". Neuron. 33 (2): 275–85. doi:10.1016/S0896-6273(01)00584-0. PMID 11804574.
  7. Xie HQ, Siow NL, Peng HB, Massoulié J, Tsim KW (Dec 2005). "Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle". Chemico-Biological Interactions. 157–158: 432. doi:10.1016/j.cbi.2005.10.093. PMID 16429581.
  8. Perrier NA, Khérif S, Perrier AL, Dumas S, Mallet J, Massoulié J (Oct 2003). "Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase". The European Journal of Neuroscience. 18 (7): 1837–47. doi:10.1046/j.1460-9568.2003.02914.x. PMID 14622217.
  9. Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, Blessed G, Fairbairn A (Sep 1983). "Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form". Neuroscience Letters. 40 (2): 199–204. doi:10.1016/0304-3940(83)90302-6. PMID 6633975.

Further reading


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