PRKRA

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.[5][6][7] PACT heterodimerizes with and activates protein kinase R.[6][8] PRKRA mutations have been linked to a rare form of dystonia parkinsonism.[9]

PRKRA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKRA, DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
External IDsOMIM: 603424 MGI: 1344375 HomoloGene: 2738 GeneCards: PRKRA
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q31.2Start178,431,414 bp[1]
End178,451,512 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8575

23992

Ensembl

ENSG00000180228

ENSMUSG00000002731

UniProt

O75569

Q9WTX2

RefSeq (mRNA)

NM_001139517
NM_001139518
NM_001316362
NM_003690

NM_011871

RefSeq (protein)

NP_001132989
NP_001132990
NP_001303291
NP_003681

NP_036001

Location (UCSC)Chr 2: 178.43 – 178.45 MbChr 2: 76.63 – 76.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000180228 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002731 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator".
  6. Patel RC, Sen GC (August 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506.
  7. Ito T, Yang M, May WS (May 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. 274 (22): 15427–32. doi:10.1074/jbc.274.22.15427. PMID 10336432.
  8. Huang X, Hutchins B, Patel RC (August 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496.
  9. Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Singleton AB (March 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology. 7 (3): 207–215. doi:10.1016/S1474-4422(08)70022-X. PMID 18243799. S2CID 206157913.

Further reading


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