PSME1

Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene.[4][5]

PSME1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPSME1, IFI5111, PA28A, PA28alpha, REGalpha, HEL-S-129m, proteasome activator subunit 1
External IDsOMIM: 600654 MGI: 1096367 HomoloGene: 4560 GeneCards: PSME1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q12Start24,136,163 bp[1]
End24,138,967 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5720

19186

Ensembl

ENSG00000092010
ENSG00000284916

ENSMUSG00000022216

UniProt

Q06323

P97371

RefSeq (mRNA)

NM_176783
NM_001281528
NM_001281529
NM_006263

NM_011189

RefSeq (protein)

NP_001268457
NP_001268458
NP_006254
NP_788955

NP_035319

Location (UCSC)Chr 14: 24.14 – 24.14 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.[5]

Interactions

PSME1 has been shown to interact with:

References

  1. ENSG00000284916 GRCh38: Ensembl release 89: ENSG00000092010, ENSG00000284916 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Honoré B, Leffers H, Madsen P, Celis JE (Feb 1994). "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111". Eur J Biochem. 218 (2): 421–30. doi:10.1111/j.1432-1033.1993.tb18392.x. PMID 8269930.
  5. "Entrez Gene: PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)".
  6. Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  8. Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (Jul 1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi:10.1074/jbc.271.30.18237. PMID 8663520.

Further reading

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