PUM1

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.[4]

PUM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPUM1, HSPUM, PUMH, PUMH1, PUML1, pumilio RNA binding family member 1, SCA47
External IDsOMIM: 607204 MGI: 1931749 HomoloGene: 22830 GeneCards: PUM1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p35.2Start30,931,506 bp[1]
End31,065,991 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9698

80912

Ensembl

ENSG00000134644

ENSMUSG00000028580

UniProt

Q14671

Q80U78

RefSeq (mRNA)

NM_014676
NM_001020658

NM_001159603
NM_001159604
NM_001159605
NM_001159606
NM_030722

RefSeq (protein)

NP_001018494
NP_055491

Location (UCSC)Chr 1: 30.93 – 31.07 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000134644 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.