Passenger leukocyte

In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted allograft sensitize the recipient's alloreactive T-lymphocytes, causing transplant rejection.[1]

The concept was first proposed by George Davis Snell[2] and the term coined in 1968 when Elkins and Guttmann showed that leukocytes present in a donor graft initiate an immune response in the recipient of a transplant.[3]

See also

References

  1. Thaunat, Olivier; Morelon, Emmanuel (2007). "Modulation of Immunogenicity". In Lanzetta, Marco; Dubernard, Jean-Michel (eds.). Hand transplantation. Springer. pp. 210–1. ISBN 978-88-470-0374-3.
  2. Snell, George D. (1957). "The homograft reaction". Annual Review of Microbiology. 11: 439–58. doi:10.1146/annurev.mi.11.100157.002255. PMID 13470828.
  3. Elkins, William L.; Guttmann, Ronald D. (1968). "Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes". Science. 159 (3820): 1250–1. Bibcode:1968Sci...159.1250E. doi:10.1126/science.159.3820.1250. PMID 4886081.

Further reading

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