Paul Thomas Sharpe

Paul Thomas Sharpe (born 12 December 1955) is a British biologist who is the Dickinson Professor of Craniofacial Biology and Director, Centre for Craniofacial and Regenerative Biology, King's College London.[1]

Paul Thomas Sharpe
Born (1955-12-11) December 11, 1955
Sheffield
NationalityBritish
Known forCellular differentiation
Spouse(s)Joy Elizabeth Sharpe (nee Mitchell)
Academic background
Alma materUniversity of York
University of Sheffield
ThesisDifferentiation of the cellular slime mould Dictyostelium discoideum (1981)
Doctoral advisorDonald J. Watt
Academic work
DisciplineBiology
InstitutionsKing's College London
Websitewww.kcl.ac.uk/people/paul-sharpe

Education

Sharpe was educated at De La Salle College, Sheffield (now All Saints Catholic High School, Sheffield) (1967-1974). He holds a BA in Biology from the University of York (1977) and a PhD from the University of Sheffield (1981).

Research

Following his doctoral work at the University of Sheffield, Sharpe continued as a postdoctoral researcher there and also at the University of Wisconsin and the University of Cambridge prior to his first academic appointment at the University of Manchester (1997). Sharpe's research focuses on cell differentiation and began with his doctoral work on differentiation of the cellular slime mould Dictyostelium discoideum but he extended this work to mammalian tissues, principally bone.[2][3] In this early work he applied the technique of thin layer countercurrent distribution.[4][5] Subsequently, through the study of mouse embryo differentiation and the role of homeobox sequences in DNA, his work has mainly been applied to the field of craniofacial development.[6][7] Most recently he has been leading research into the possibility of tooth regeneration and the development of new biological-based treatments for tooth repair.[8][9][10][11][12] Sharpe is author of Methods of Cell Separation.[13]

Awards and recognition

Sharpe is an Honorary Fellow of the Royal College of Surgeons in Edinburgh (2010) and a recipient of the Gregor Mendel Memorial Medal (2003).[14] He was awarded the Craniofacial Biology Research Award by the International Association for Dental Research (2004) and 2018 he received the William J Gies award for best publication is Biomaterials and Bioengineering (2018).[15]

Personal life

Sharpe (stage name Paul Shaft) is a musician and was a pioneer of the Sheffield punk music and new wave music scene. Originally he played bass guitar in the Sheffield band 2.3 and then formed the avante garde band De Tian.[16][17] He later played double bass and sang in the experimental jazz influenced band, Bass Tone Trap.[18] Sharpe (Shaft) reformed 2.3 in 2018 and they have released two albums.[19][20] Sharpe, a lifelong supporter of Sheffield United F.C. is married to Joy Elizabeth Sharpe (nee Mitchell) and they have two children.[21]

Bibliography

Sharpe has over 300 publications listed on Web of Science which have been cited more than 14,500 times; his h-index is 66. His three most-cited articles are:

  • Theslef, I; Sharpe, P (1997). "Signalling networks regulating dental development". Mechanisms of Development. 67 (2): 111–123. doi:10.1016/s0925-4773(97)00115-9. PMID 9392510. S2CID 14900117.
  • Qui, MS; Bulfone, A; Ghattas-Fernandez, I; Meneses, JJ; Christensen, L; Sharpe, PT; Presley, R; Pedersen, RA; Rubenstein, JLR (1997). "Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: Mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches". Developmental Biology. 185 (2): 165–184. doi:10.1006/dbio.1997.8556. PMID 9187081.
  • Tucker, A; Sharpe, P (2004). "The cutting-edge of mammalian development; how the embryo makes teeth". Nature Reviews Genetics. 5 (7): 499–508. doi:10.1038/nrg1380. PMID 15211352. S2CID 42067451.

References
  1. "Professor Paul Sharpe". King's College London. Retrieved 27 May 2020.
  2. Sharpe, PT; Treffry, TE; Watts, DJ (1982). "Studies of early stages of differentiation of the cellular slime mould Dictyostelium discoideum". Development. 67: 181–193.
  3. Sharpe, PT; Gallagher, JA; Treffry, TE; Russell, RGG (1982). "Studies of the growth of human bone-derived cells in culture using aqueous two-phase partition". Bioscience Reports. 4 (5): 415–419. doi:10.1007/BF01122506. PMID 6203567. S2CID 46613754.
  4. Albertsson, P-A (1965). "Thin-layer countercurrent distribution". Analytical Biochemistry. 4: 121–125. doi:10.1016/0003-2697(65)90050-3. PMID 14328632.
  5. Sharpe, PT; Watts, DJ (1985). "Use of aqueous two-phase partition to detect cell surface changes during growth of D. discoideum". J. Cell Sci. 75: 339–346.
  6. Gaunt, SJ; Sharpe, PT; Duboule, D (1988). "Spatially-restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan". Development. 104: 169–181.
  7. Gaunt, SJ; Coletta, PL; Sharpe, PT (1988). "Mouse Hox- 3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network". Development. 109 (2): 329–341. PMID 1976088.
  8. "Common origin identified could bring tooth regeneration potential closer". Eurekalert. Retrieved 8 May 2020.
  9. "Could an Alzheimer's drug be the key to dental regeneration?: an interview with Paul Sharpe". RegMedNet. Retrieved 8 May 2020.
  10. "Natural tooth repair method, using Alzheimer's drug, could revolutionize dental treatments". MedicalXPress. Retrieved 8 May 2020.
  11. Neves, VC; Babb, R; Chandrasekaran, D; Sharpe, PT (2017). "Promotion of natural tooth repair by small molecule GSK3 antagonists". Scientific Reports. 9 (7): 39654. Bibcode:2017NatSR...739654N. doi:10.1038/srep39654. PMC 5220443. PMID 28067250.
  12. "Adult stem cells could treat tooth loss". The Royal Society. Retrieved 27 May 2020.
  13. "Methods of Cell Separation". Elsevier. Retrieved 27 May 2020.
  14. "Honorary Fellow of the Royal College of Surgeons in Edinburgh". ORCID. Retrieved 8 May 2020.
  15. "Professor Paul Sharpe". King' College London. Retrieved 8 May 2020.
  16. "2.3". Sheffield Vision. Retrieved 8 May 2020.
  17. "De Tian". Discogs. Retrieved 8 May 2020.
  18. "Bass Tone Trap". Sheffield Music Archive. Retrieved 27 May 2020.
  19. "New Clear Waves". Discogs. Retrieved 11 May 2020.
  20. "Songs of the Lost". Bandcamp. Retrieved 11 May 2020.
  21. "Self-Repairing Of The Teeth – An Interview With Professor Sharpe". Youth Time. Retrieved 27 May 2020.
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