Pho1 family

The Pho1 phosphate permease family (TC# 2.A.94) is a family of phosphate transporters belonging to the ion transporter (IT) superfamily.[1] Representative members of the Pho1 family include the putative phosphate transporter PHO1 of Arabidopsis thaliana (TC# 2.A.94.1.1), and the xenotropic and polytropic murine-leukemia virus receptor Xpr1 of Culex pipiens (TC# 2.A.94.1.2).

Pho1

Pho1 of A. thaliana is a member of the PHO1 family (11 paralogues in A. thaliana). This protein is 782 amino acyl residues in length and possesses 7 transmembrane segments (TMSs). It functions in inorganic phosphate transport and homeostasis. Pho1 catalyzes efflux of phosphate from epidermal and cortical cells into the xylem.[2][3] The SPX superfamily domain is an N-terminal soluble domain. These proteins belong to the EXS (Erd1/Xpr1/Syg1) superfamily.

The generalized reaction catalyzed by Pho1 is:[4]

Pi (cells) → Pi (xylem)

See also

Further reading

References
  1. Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
  2. Quaghebeur, Mieke; Rengel, Zed (2004-02-01). "Arsenic uptake, translocation and speciation in pho1 and pho2 mutants of Arabidopsis thaliana". Physiologia Plantarum. 120 (2): 280–286. doi:10.1111/j.0031-9317.2004.0240.x. ISSN 1399-3054. PMID 15032863.
  3. Stefanovic, Aleksandra; Ribot, Cécile; Rouached, Hatem; Wang, Yong; Chong, Julie; Belbahri, Lassaad; Delessert, Syndie; Poirier, Yves (2007-06-01). "Members of the PHO1 gene family show limited functional redundancy in phosphate transfer to the shoot, and are regulated by phosphate deficiency via distinct pathways". The Plant Journal. 50 (6): 982–994. doi:10.1111/j.1365-313X.2007.03108.x. ISSN 0960-7412. PMID 17461783.
  4. "2.A.94 The Phosphate Permease (Pho1) Family". Transporter Classification Database. Retrieved 2016-03-03.


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