Polyamine-modulated factor 1

PMF1
Identifiers
Aliases	PMF1, polyamine modulated factor 1
External IDs	OMIM: 609176 MGI: 1914287 HomoloGene: 5224 GeneCards: PMF1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,240,042 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	88,410,331 bp[2]
Gene ontology
Molecular function	• GO:0001105 transcription coactivator activity; • leucine zipper domain binding; • GO:0001948 protein binding;
Cellular component	• chromosome; • cytosol; • MIS12/MIND type complex; • chromosome, centromeric region; • cell nucleus; • kinetochore; • transcription regulator complex; • nucleoplasm; • Golgi apparatus; • intracellular membrane-bounded organelle; • condensed chromosome kinetochore; • nuclear MIS12/MIND complex;
Biological process	• chromosome segregation; • cell division; • cell cycle; • regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • transcription, DNA-templated; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11243
	67037
	ENSG00000160783
	ENSMUSG00000028066
	Q6P1K2
	Q9CPV5
	NM_007221; NM_001199653; NM_001199654
	NM_025928; NM_001310605
	NP_001186582; NP_001186583; NP_009152
	NP_001297534; NP_080204
	Wikidata
View/Edit Human	View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.[5][6]

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.[7][8]

References

GRCh38: Ensembl release 89: ENSG00000160783 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028066 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
"Entrez Gene: PMF1 polyamine-modulated factor 1".
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.

Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160783 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028066 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419538-5] Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.

[entrez-6] "Entrez Gene: PMF1 polyamine-modulated factor 1".

[pmid15371340-7] Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.

[pmid15502821-8] Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.

Polyamine-modulated factor 1

Interactions

References

Further reading