MIS12

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.[5][6][7]

MIS12
Identifiers
AliasesMIS12, 2510025F08Rik, KNTC2AP, MTW1, hMis12, kinetochore complex component, MIS12 kinetochore complex component
External IDsOMIM: 609178 MGI: 1914389 HomoloGene: 11429 GeneCards: MIS12
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start5,486,285 bp[1]
End5,490,814 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79003

67139

Ensembl

ENSG00000167842

ENSMUSG00000040599

UniProt

Q9H081

Q9CY25

RefSeq (mRNA)

NM_001258217
NM_001258218
NM_001258219
NM_001258220
NM_024039

NM_025993

RefSeq (protein)

NP_001245146
NP_001245147
NP_001245148
NP_001245149
NP_076944

NP_080269

Location (UCSC)Chr 17: 5.49 – 5.49 MbChr 11: 71.02 – 71.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

MIS12 has been shown to interact with NSL1,[8] ZWINT,[8][9] CASC5,[8][9] Polyamine-modulated factor 1,[8][9] NDC80,[8][9] DSN1[8][9] and CBX5.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000167842 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040599 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. Goshima G, Kiyomitsu T, Yoda K, Yanagida M (Jan 2003). "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway". J Cell Biol. 160 (1): 25–39. doi:10.1083/jcb.200210005. PMC 2172742. PMID 12515822.
  7. "Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast)".
  8. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.
  9. Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340.

Further reading


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