Power Book II: Ghost

• Michael Rainey Jr. as Tariq St. Patrick, the son of James "Ghost" St. Patrick and Tasha Green-St. Patrick, Who is slowly following his father's steps as a drug dealer
• Shane Johnson as Cooper Saxe, the attorney prosecuting Tasha, following failed attempts to catch Ghost
• Gianni Paolo as Brayden Weston, Tariq's best friend and former roommate at Choate and Current room mate at Stanfield, he is also selling drugs with Tariq
• Melanie Liburd as Caridad "Carrie" Milgram, one of Tariq's professors who has a secret relationship with Zeke
• Lovell Adams-Gray as Dru Tejada, Monet’s son and brother of Cane and Diana
• Daniel Bellomy as Ezekiel "Zeke" Cross, Monet's nephew and Carrie's new love interest
• Quincy Tyler Bernstine as Tameika Washington, an attorney formerly affiliated with Saxe
• Paige Hurd as Lauren Baldwin, Tariq's classmate and love interest
• Woody McClain as Cane Tejada, ruthless gangster and brother of Dru and Diana
• Justin Marcel McManus as Jabari Reynolds, Carrie's ex-boyfriend and Tariq’s professor (season 1)
• Method Man as Davis Maclean, Tasha’s lawyer who looks to win at all costs
• LaToya Tonodeo as Diana Tejada, Sister of Dru and Cane who is also in the drug business and Tariq's love interest
• Mary J. Blige as Monet Stewart Tejada, queenpin of the Tejada drug cartel. Mother of Cane, Dru and Diana
• Naturi Naughton as Tasha St. Patrick, Tariq’s mother and Ghost’s ex-wife

• Kathleen Garrett as Judge Nina Larkin, the judge presiding over Tasha St. Patrick's case
• Debbi Morgan as Estelle Green, Tasha's mother
• Paris Morgan as Yasmine St. Patrick, Tariq's little sister & Tasha's daughter
• Victor Garber as Simon Stern, Ghost's former business partner
• Sung Kang as John Mak, an attorney formerly involved in the Lobos-Ghost investigation
• Mark Feuerstein as Steven Ott, the representative of the political party Ghost was part of
• Sherri Saum as Paula Matarazzo, top investigator and right hand of Davis MacLean
• Berto Colon as Lorenzo Tejada, Monet's incarcerated husband, the real leader of the Tejada operation
• Shalim Ortiz as Danilo Ramirez, an NYPD officer stationed in the Tejadas’ backyard of Queens, NY, and Monet's boyfriend (season 1)
• Lightskin Keisha as BruShandria Carmichael, Tariq's classmate
• Larenz Tate as Councilman Rashad Tate, Ghost's former political rival
• Glynn Turman as Gabriel, uncle to Ghost
• Brandi Denise Boyd as Epiphany Turner, a stripper single mom, who worked together with Tasha
• Cory Jeacoma as Trace Weston, Brayden's entitled brother
• Marcus Anderson Jr. as Lil' Guap, the Tejada's partner, before Tariq
• Monique Gabriela Curnen as Blanca Rodriguez
• David Zayas as Uncle Frank, a relative of the Tejadas who tried to set them up (season 1)
• Brittani Tucker as Chelle, Rel's ex-girlfriend now Cane’s girlfriend
• Andrea Lee Christensen as Riley Saxe-Merchant, Cooper's niece and Brayden's new love interest
• Donshea Hopkins as Raina St. Patrick, Tariq's twin sister
• Bradley Gibson as Everett Neal, Dru's new love interest
• Michael J. Ferguson as Francis "2-Bit" Johnson, a convicted felon formerly associated with Andre Coleman and Tommy Egan
• Elizabeth Rodriguez as Paz Valdes, Angela Valdes' sister
• Luenell Campbell as Ms. Richards, Spanky's mother
• Alix Lapri as Effie, Tariq's former business partner/girlfriend at Choate
• Laz Alonso as Samuel Santana, a detective investigating the death of the GTG assassin on the faculty grounds
• Jackie Long as Rico Barnes, the man who provides the drugs for the Tejadas to distribute (season 1)
• Joseph Sikora as Tommy Egan, Ghost’s childhood best friend
• Denim Roberson as Cash Grant, LaKeisha Grant's son and Tommy's surrogate son

On July 26, 2019, Starz announced the straight-to-series order with the news that Mary J. Blige would star.[14] On February 9, 2020, Starz announced the premise of the series.[15] On September 22, 2020, Starz renewed the series for a second season.[2]

Mary J. Blige was cast on July 26, 2019, with the initial news. On January 14, 2020, Method Man was cast in a main role.[16] The remainder of the main cast was entirely announced on February 9, 2020.[17] On July 21, 2020, Sherri Saum was cast for the series.[18] Two days later, Shalim Ortiz was cast in a recurring role.[19]