Protein THEMIS

THEMIS
Identifiers
Aliases	THEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated
External IDs	OMIM: 613607 MGI: 2443552 HomoloGene: 72287 GeneCards: THEMIS
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	127,918,631 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	28,883,818 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• cytoplasm; • COP9 signalosome; • cell nucleus; • intercellular junction;
Biological process	• multicellular organism development; • T cell receptor signaling pathway; • adaptive immune response; • negative selection; • positive T cell selection; • immune system process;
	Sources:Amigo / QuickGO
Orthologs
	387357
	210757
	ENSG00000275122; ENSG00000172673
	ENSMUSG00000049109
	Q8N1K5
	Q8BGW0
	NM_001010923; NM_001164685; NM_001164687; NM_001318531
	NM_178666; NM_001305663; NM_001374699
	NP_001010923; NP_001158157; NP_001158159; NP_001305460
	NP_001292592; NP_848781; NP_001361628
	Wikidata
View/Edit Human	View/Edit Mouse

Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.[5][6][7]

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[8]

The name

THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[9]

References

ENSG00000172673 GRCh38: Ensembl release 89: ENSG00000275122, ENSG00000172673 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049109 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
"Entrez Gene: thymocyte selection associated".
Zielinska E (2009-11-01). "Six degrees of science". The Scientist.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Allen PM (2009). "Themis imposes new law and order on positive selection". Nat. Immunol. 10 (8): 805–6. doi:10.1038/ni0809-805. PMID 19621038. S2CID 205359914.

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[refGRCh38Ensembl-1] ENSG00000172673 GRCh38: Ensembl release 89: ENSG00000275122, ENSG00000172673 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049109 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19597499-5] Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.

[pmid19597498-6] Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.

[pmid19597497-7] Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.

[entrez-8] "Entrez Gene: thymocyte selection associated".

[url_Six_degrees_of_science-9] Zielinska E (2009-11-01). "Six degrees of science". The Scientist.

Protein THEMIS

Function

The name

References

Further reading