Proteus phenomenon

The Proteus phenomenon is the tendency in science for early replications of a work to contradict the original findings, a consequence of publication bias.[1] It is akin to the winner's curse.[2]

This article is about a statistical bias in academic publishing. For the aspect of human psychology, see Proteus effect.

The term was coined by John Ioannidis and Thomas A. Trikalinos in 2005 named after the Greek god Proteus who could rapidly change his appearance.[3] A 2013 paper argued that the phenomenon might be "desirable or even optimal" from a scientific standpoint.[4]

See also

References
  1. Pfeiffer, Thomas; Bertram, Lars; Ioannidis, John (2011). "Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar bias". PLoS ONE. 6 (3): e18362. doi:10.1371/journal.pone.0018362. PMC 3066227. PMID 21479240.
  2. Button, Katherine S.; et al. (2013). "Power failure: why small sample size undermines the reliability of neuroscience". Nature Reviews Neuroscience. 14 (5): 365–376. doi:10.1038/nrn3475. PMID 23571845.
  3. Ioannidis, JP; Trikalinos, TA (2005). "Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomised trials". Journal of Clinical Epidemiology. 58: 543–549. doi:10.1016/j.jclinepi.2004.10.019.
  4. de Winter, Joost; Happee, Riender (20 June 2013). "Why Selective Publication of Statistically Significant Results Can Be Effective". PLoS ONE. 8 (6): e66463. doi:10.1371/journal.pone.0066463. PMC 3688764. PMID 23840479.
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