RAD23A

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.[5]

RAD23A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAD23A, HHR23A, HR23A, RAD23 homolog A, nucleotide excision repair protein
External IDsOMIM: 600061 MGI: 105126 HomoloGene: 48322 GeneCards: RAD23A
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.13Start12,945,855 bp[1]
End12,953,642 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5886

19358

Ensembl

ENSG00000179262

ENSMUSG00000003813

UniProt

P54725

P54726

RefSeq (mRNA)

NM_001270362
NM_001270363
NM_005053

RefSeq (protein)

NP_001257291
NP_001257292
NP_005044

Location (UCSC)Chr 19: 12.95 – 12.95 MbChr 8: 84.83 – 84.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.[6]

Interactions

RAD23A has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000179262 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003813 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics. 23 (3): 651–658. doi:10.1006/geno.1994.1554. hdl:1765/3069. PMID 7851894.
  6. "Entrez Gene: RAD23A RAD23 homolog A (S. cerevisiae)".
  7. Wang G, Sawai N, Kotliarova S, Kanazawa I, Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–803. doi:10.1093/hmg/9.12.1795. PMID 10915768.
  8. Hiyama H, Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers JH, Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–25. doi:10.1074/jbc.274.39.28019. PMID 10488153.
  9. Mueller TD, Feigon J (September 2003). "Structural determinants for the binding of ubiquitin-like domains to the proteasome". EMBO J. 22 (18): 4634–45. doi:10.1093/emboj/cdg467. PMC 212733. PMID 12970176.
  10. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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