RALBP1

RALBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KWH, 2KWI, 2MBG
Identifiers
Aliases	RALBP1, RIP1, RLIP1, RLIP76, ralA binding protein 1
External IDs	OMIM: 605801 MGI: 108466 HomoloGene: 4940 GeneCards: RALBP1
Gene location (Human)
Chr.	Chromosome 18 (human)[1]
End	9,538,114 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	65,885,798 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • Ral GTPase binding; • Rac GTPase binding; • GO:0022891 transmembrane transporter activity; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • GO:0015238 xenobiotic transporter activity; • ATPase activity, coupled to transmembrane movement of substances;
Cellular component	• cytosol; • membrane;
Biological process	• endocytosis; • regulation of small GTPase mediated signal transduction; • transmembrane transport; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • chemotaxis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • signal transduction; • small GTPase mediated signal transduction; • drug transmembrane transport; • doxorubicin transport; • drug transmembrane export;
	Sources:Amigo / QuickGO
Orthologs
	10928
	19765
	ENSG00000017797
	ENSMUSG00000024096
	Q15311
	Q62172
	NM_006788
	NM_001198949; NM_009067
	NP_006779
	NP_001185878; NP_033093
	Wikidata
View/Edit Human	View/Edit Mouse

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.[5][6]

Interactions

RALBP1 has been shown to interact with:

References

GRCh38: Ensembl release 89: ENSG00000017797 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024096 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH (Oct 1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J Biol Chem. 270 (38): 22473–7. doi:10.1074/jbc.270.38.22473. PMID 7673236.
"Entrez Gene: RALBP1 ralA binding protein 1".
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (Aug 2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.
Hu Y, Mivechi NF (May 2003). "HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200. PMID 12621024.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
Cantor SB, Urano T, Feig LA (Aug 1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. doi:10.1128/mcb.15.8.4578. PMC 230698. PMID 7623849.
Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (Jan 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Awasthi S, Sharma R, Singhal SS, Zimniak P, Awasthi YC (2003). "RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics". Drug Metab. Dispos. 30 (12): 1300–10. doi:10.1124/dmd.30.12.1300. PMID 12433796.
Yamaguchi A, Urano T, Goi T, Feig LA (1998). "An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1". J. Biol. Chem. 272 (50): 31230–4. doi:10.1074/jbc.272.50.31230. PMID 9395447.
Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
Iouzalen N, Camonis J, Moreau J (1998). "Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein". Biochem. Biophys. Res. Commun. 250 (2): 359–63. doi:10.1006/bbrc.1998.9336. PMID 9753634.
Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L (2000). "Involvement of Ras and Ral in Chemotactic Migration of Skeletal Myoblasts". Mol. Cell. Biol. 20 (13): 4658–65. doi:10.1128/MCB.20.13.4658-4665.2000. PMC 85875. PMID 10848592.
Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis". J. Cell Sci. 113 (16): 2837–44. PMID 10910768.
Awasthi S, Cheng J, Singhal SS, Saini MK, Pandya U, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC (2000). "Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin". Biochemistry. 39 (31): 9327–34. doi:10.1021/bi992964c. PMID 10924126.
Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC (2001). "RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes". Arch. Biochem. Biophys. 391 (2): 171–9. doi:10.1006/abbi.2001.2395. PMID 11437348.
Singhal SS, Singhal J, Cheng J, Pikuła S, Sharma R, Zimniak P, Awasthi YC, Awasthi S (2002). "Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes". Acta Biochim. Pol. 48 (2): 551–62. doi:10.18388/abp.2001_3938. PMID 11732624.
Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
Singhal SS, Singhal J, Sharma R, Singh SV, Zimniak P, Awasthi YC, Awasthi S (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells". Int. J. Oncol. 22 (2): 365–75. doi:10.3892/ijo.22.2.365. PMID 12527936.
Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76". Int. J. Oncol. 22 (4): 713–20. doi:10.3892/ijo.22.4.713. PMID 12632060.
Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC (2003). "Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity". Int. J. Oncol. 22 (4): 721–32. doi:10.3892/ijo.22.4.721. PMID 12632061.
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
Gómez MI, Lee A, Reddy B, Muir A, Soong G, Pitt A, Cheung A, Prince A (2004). "Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1". Nat. Med. 10 (8): 842–8. doi:10.1038/nm1079. PMID 15247912. S2CID 1851441.
Zhang H, Zhang R, Luo Y, D'Alessio A, Pober JS, Min W (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200. PMID 15310755.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000017797 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024096 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7673236-5] Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH (Oct 1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J Biol Chem. 270 (38): 22473–7. doi:10.1074/jbc.270.38.22473. PMID 7673236.

[entrez-6] "Entrez Gene: RALBP1 ralA binding protein 1".

[pmid12775724-7] Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (Aug 2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.

[pmid12621024-8] Hu Y, Mivechi NF (May 2003). "HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200. PMID 12621024.

[pmid14525976-9] Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.

[pmid7623849-10] Cantor SB, Urano T, Feig LA (Aug 1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. doi:10.1128/mcb.15.8.4578. PMC 230698. PMID 7623849.

[pmid9422736-11] Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (Jan 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.

[pmid16189514-12] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

RALBP1

Interactions

References

Further reading