RGS7

RGS7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A72, 2D9J
Identifiers
Aliases	RGS7, regulator of G protein signaling 7
External IDs	OMIM: 602517 MGI: 1346089 HomoloGene: 2193 GeneCards: RGS7
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	241,357,230 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	175,492,500 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• G-protein beta-subunit binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • GTPase activity;
Cellular component	• cytosol; • membrane; • cytoplasm; • cell membrane; • heterotrimeric G-protein complex;
Biological process	• G-protein coupled receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • negative regulation of signal transduction; • GO:0007243 intracellular signal transduction; • protein folding;
	Sources:Amigo / QuickGO
Orthologs
	6000
	24012
	ENSG00000182901
	ENSMUSG00000026527
	P49802
	O54829
NM_001282773; NM_001282775; NM_001282778; NM_002924; NM_001350113;
	NM_001350114; NM_001350115; NM_001350116; NM_001364886; NM_001374806; NM_001374807; NM_001374808; NM_001374809; NM_001374810; NM_001374811; NM_001374812; NM_001374813; NM_001374814; NM_001374815; NM_001374816
	NM_001199003; NM_011880; NM_001347195; NM_001357129
NP_001269702; NP_001269704; NP_001269707; NP_002915; NP_001337042;
	NP_001337043; NP_001337044; NP_001337045; NP_001351815; NP_001361735; NP_001361736; NP_001361737; NP_001361738; NP_001361739; NP_001361740; NP_001361741; NP_001361742; NP_001361743; NP_001361744; NP_001361745
	NP_001185932; NP_001334124; NP_036010; NP_001344058
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.[5][6]

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.[7]

Interactions

RGS7 has been shown to interact with:

References

GRCh38: Ensembl release 89: ENSG00000182901 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026527 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815. S2CID 7815240.
"Entrez Gene: RGS7 regulator of G-protein signalling 7".
Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.

Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". J. Neurochem. 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi:10.1074/jbc.274.14.9899. PMID 10092682.
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity". J. Biol. Chem. 275 (36): 28167–72. doi:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms". J. Neurochem. 75 (5): 2103–12. doi:10.1046/j.1471-4159.2000.0752103.x. PMID 11032900. S2CID 20156736.
Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF (2001). "Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain". J. Biol. Chem. 276 (13): 10284–9. doi:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E (2002). "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha". J. Biol. Chem. 277 (36): 32954–62. doi:10.1074/jbc.M200859200. PMID 12077120.
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.
Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction". J. Biol. Chem. 278 (23): 21307–13. doi:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" (PDF). Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. S2CID 7710900.
Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMC 1405920. PMID 15496508.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism". J. Biol. Chem. 281 (38): 28222–31. doi:10.1074/jbc.M604428200. PMID 16867977.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182901 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026527 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8548815-5] Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815. S2CID 7815240.

[entrez-6] "Entrez Gene: RGS7 regulator of G-protein signalling 7".

[7] Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673.

[pmid10051672-8] Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.

[pmid10521509-9] Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.

[:0-10] Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.

[pmid10339594-11] Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.

[pmid12659861-12] Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.

RGS7

Interactions

References

Further reading