RRAS

Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.[5][6]

RRAS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRRAS, related RAS viral (r-ras) oncogene homolog, R-Ras, RAS related
External IDsOMIM: 165090 MGI: 98179 HomoloGene: 4565 GeneCards: RRAS
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start49,635,292 bp[1]
End49,640,143 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6237

20130

Ensembl

ENSG00000126458

ENSMUSG00000038387

UniProt

P10301

P10833

RefSeq (mRNA)

NM_006270

NM_009101
NM_001360132
NM_001360133

RefSeq (protein)

NP_006261

NP_033127
NP_001347061
NP_001347062

Location (UCSC)Chr 19: 49.64 – 49.64 MbChr 7: 45.02 – 45.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RRAS has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000126458 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038387 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell. 48 (1): 137–46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437. S2CID 22622027.
  6. "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog".
  7. Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/s0888-7543(02)00008-3. PMID 12620389.
  8. Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/mcb.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
  9. Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. 366 (6452): 274–5. doi:10.1038/366274a0. PMID 8232588. S2CID 4312803.
  10. Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. 275 (7): 5222–7. doi:10.1074/jbc.275.7.5222. PMID 10671570.
  11. Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
  12. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

Further reading


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