SBF1

SBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5U
Identifiers
Aliases	SBF1, CMT4B3, DENND7A, MTMR5, SET binding factor 1
External IDs	OMIM: 603560 MGI: 1925230 HomoloGene: 84710 GeneCards: SBF1
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	50,475,035 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	89,315,311 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• phosphatase regulator activity; • protein tyrosine/serine/threonine phosphatase activity; • guanyl-nucleotide exchange factor activity; • Rab guanyl-nucleotide exchange factor activity; • phosphatase activity;
Cellular component	• integral component of membrane; • cell nucleus; • cytosol; • endoplasmic reticulum membrane; • cytoplasm; • nuclear body; • perinuclear region of cytoplasm;
Biological process	• GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • protein dephosphorylation; • spermatogenesis; • phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6305
	77980
	ENSG00000100241
	ENSMUSG00000036529
	O95248
	Q6ZPE2
	NM_002972; NM_001365819
	NM_001081030; NM_001170561; NM_030019
	NP_002963; NP_001352748
	NP_001074499; NP_001164032
	Wikidata
View/Edit Human	View/Edit Mouse

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.[5][6][7]

Interactions

SBF1 has been shown to interact with MTMR2[8] and SUV39H1.[9]

GRCh38: Ensembl release 89: ENSG00000100241 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036529 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414.
Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
"Entrez Gene: SBF1 SET binding factor 1".
Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.
Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.

Overview of all the structural information available in the PDB for UniProt: Q6ZPE2 (Mouse Myotubularin-related protein 5) at the PDBe-KB.

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