SEC23B

SEC23B
Identifiers
Aliases	SEC23B, CDA-II, CDAII, CDAN2, HEMPAS, CWS7, Sec23 homolog B, coat complex II component, hSec23B, SEC23 homolog B, COPII coat complex component
External IDs	OMIM: 610512 MGI: 1350925 HomoloGene: 74571 GeneCards: SEC23B
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	18,561,415 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	144,590,749 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• zinc ion binding; • GO:0001948 protein binding; • metal ion binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity;
Cellular component	• perinuclear region of cytoplasm; • COPII vesicle coat; • endoplasmic reticulum membrane; • endomembrane system; • endoplasmic reticulum; • membrane; • cytoplasm; • cytosol; • ER to Golgi transport vesicle membrane; • cytoplasmic vesicle; • Golgi membrane; • endoplasmic reticulum exit site;
Biological process	• protein transport; • ER to Golgi vesicle-mediated transport; • intracellular protein transport; • vesicle-mediated transport; • COPII-coated vesicle budding; • regulation of COPII vesicle coating; • Golgi organization; • regulation of cell shape; • macroautophagy; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cargo loading into COPII-coated vesicle;
	Sources:Amigo / QuickGO
Orthologs
	10483
	27054
	ENSG00000101310
	ENSMUSG00000027429
	Q15437; Q5QPE2
	Q9D662
	NM_032986; NM_001172745; NM_001172746; NM_006363; NM_032985
NM_001252543; NM_001252544; NM_001252545; NM_001281816; NM_019787;
	NM_001355379; NM_001355380
	NP_001166216; NP_001166217; NP_006354; NP_116780; NP_116781
NP_001239472; NP_001239473; NP_001239474; NP_001268745; NP_062761;
	NP_001342308; NP_001342309
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.[5][6][7]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[7] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References

GRCh38: Ensembl release 89: ENSG00000101310 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027429 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.
Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
"Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101310 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027429 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8898360-5] Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell. 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.

[pmid10329445-6] Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.

[entrez-7] "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

SEC23B

References

Further reading