SEC31A

Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.[5][6][7]

SEC31A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEC31A, ABP125, ABP130, HSPC334, SEC31L1, HSPC275, SEC31 homolog A, COPII coat complex component, NEDSOSB
External IDsOMIM: 610257 MGI: 1916412 HomoloGene: 42056 GeneCards: SEC31A
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.22Start82,818,509 bp[1]
End82,901,166 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22872

69162

Ensembl

ENSG00000138674

ENSMUSG00000035325

UniProt

O94979

Q3UPL0

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 82.82 – 82.9 MbChr 5: 100.36 – 100.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is similar to the SEC31 protein from yeast. The yeast SEC31 protein is known to be a component of the COPII protein complex, which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000138674 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035325 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. Tang BL, Zhang T, Low DY, Wong ET, Horstmann H, Hong W (May 2000). "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport". The Journal of Biological Chemistry. 275 (18): 13597–604. doi:10.1074/jbc.275.18.13597. PMID 10788476.
  7. "Entrez Gene: SEC31A SEC31 homolog A (S. cerevisiae)".

Further reading

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