SELENBP1

Selenium-binding protein 1 is a protein that in humans is encoded by the SELENBP1 gene.[5][6]

SELENBP1
Identifiers
AliasesSELENBP1, HEL-S-134P, LPSB, SBP56, SP56, hSBP, selenium binding protein 1, MTO, EHMTO
External IDsOMIM: 604188 MGI: 104859 HomoloGene: 2930 GeneCards: SELENBP1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start151,364,304 bp[1]
End151,372,707 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8991

20342

Ensembl

ENSG00000143416

ENSMUSG00000068877

UniProt

Q13228

Q63836

RefSeq (mRNA)

NM_001258288
NM_001258289
NM_003944

NM_019414

RefSeq (protein)

NP_001245217
NP_001245218
NP_003935

NP_062287

Location (UCSC)Chr 1: 151.36 – 151.37 MbChr 3: 94.69 – 94.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene product belongs to the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known.[6]

Interactions

SELENBP1 has been shown to interact with USP33.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143416 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000068877 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chang PW, Tsui SK, Liew C, Lee CC, Waye MM, Fung KP (February 1997). "Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein". Journal of Cellular Biochemistry. 64 (2): 217–24. doi:10.1002/(SICI)1097-4644(199702)64:2<217::AID-JCB5>3.0.CO;2-#. PMID 9027582.
  6. "Entrez Gene: SELENBP1 selenium binding protein 1".
  7. Jeong JY, Wang Y, Sytkowski AJ (February 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochemical and Biophysical Research Communications. 379 (2): 583–8. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.

Further reading


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