USP33

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.[5][6]

USP33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP33, VDU1, ubiquitin specific peptidase 33
External IDsOMIM: 615146 MGI: 2159711 HomoloGene: 8996 GeneCards: USP33
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.1Start77,695,987 bp[1]
End77,759,852 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23032

170822

Ensembl

ENSG00000077254

ENSMUSG00000025437

UniProt

Q8TEY7

Q8R5K2

RefSeq (mRNA)

NM_015017
NM_201624
NM_201626

NM_001076676
NM_001252486
NM_133247
NM_001355666

RefSeq (protein)

NP_001070144
NP_001239415
NP_573510
NP_001342595

Location (UCSC)Chr 1: 77.7 – 77.76 MbChr 3: 152.35 – 152.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

USP33 has been shown to interact with DIO2,[7] SELENBP1[8] and Von Hippel–Lindau tumor suppressor.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000077254 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025437 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. "Entrez Gene: USP33 ubiquitin specific peptidase 33".
  7. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
  8. Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
  9. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

Further reading


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