SMIM11A

SMIM11A, or small integral membrane protein 11A, is a protein which in humans is encoded by the C21orf51 gene.[1][2][3]

Gene

Locus

SMIM11A is located at 21q22.11 on the plus strand of chromosome 21 and has 4 exons.[3] SMIM11A is on the sense strand and spans from base 34,375,450 to 34,402,777.

Expression of SMIM11A in human tissue samples

Expression

The expression of SMIM11A is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues.[3]

mRNA

There are no known transcript variants or isoforms of SMIM11A.[4]

Protein

The SMIM11A protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.[5] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.[6][7]

Domains, Motifs, and Post-translational Modifications

SMIM11A contains a transmembrane domain.[8]. The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine[9][10]

Secondary Structure and Tertiary Structure

The protein is composed mostly of alpha-helices.[11] The N-terminus of SMIM11A sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.[12]

Tertiary Structure of SMIM11A

Quaternary Structure and Protein Interactions

Experimentally-determined protein interactions for SMIM11A have not yet been identified. .[13]

Concenptual translation of SMIM11A

Homology and Evolution

Paralogs

No paralogs or paralogous domains exist for SMIM11A

Orthologs

SMIM11A has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.[14]

Ortholog Table of SMIM11A

References
  1. "SMIM11A - Small integral membrane protein 11A - Homo sapiens (Human) - SMIM11A gene & protein". www.uniprot.org. UniProt. Retrieved 2019-05-20.
  2. "RCSB PDB - Gene View - SMIM11A - small integral membrane protein 11A". www.rcsb.org. Protein Data Bank. Retrieved 2019-05-20.
  3. "SMIM11A small integral membrane protein 11A [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "SMIM11A Protein Coding". genecards.org.
  5. "Compute pI/Mw Tool Expasy". expasy.org.
  6. "PSORT II Server". psort.hgc.jp.
  7. "Immunohistochemistry of SMIM11A: The Human Protein Atlas". proteinatlas.org.
  8. "Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA". ncbi.nlm.nih.gov. NCBI (National Center for Biotechnology Information).
  9. "iPTMnet Report for P58511 (SMIM11A)". research.bioinformatics.udel.edu.
  10. "NetPhos 3.1 Server". cbs.dtu.dk.
  11. "Phyre2 Results". sbg.bio.ic.ac.uk.
  12. "TMHHM Server". cbs.dtu.dk.
  13. "STRING FAM165B". string-db.org.
  14. "NCBI Protein Blast". blast.ncbi.nlm.nih.gov.
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