SRGAP3

SRGAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Identifiers
Aliases	SRGAP3, ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase activating protein 3
External IDs	OMIM: 606525 MGI: 2152938 HomoloGene: 56686 GeneCards: SRGAP3
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	9,363,053 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	112,947,266 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• Rac GTPase binding; • GO:0001948 protein binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity;
Cellular component	• cytoplasm; • cytosol;
Biological process	• negative regulation of cell migration; • regulation of small GTPase mediated signal transduction; • signal transduction; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	9901
	259302
	ENSG00000196220
	ENSMUSG00000030257
	O43295
	Q812A2
	NM_001033116; NM_001033117; NM_014850
	NM_080448; NM_153070
	NP_001028289; NP_055665
	NP_536696
	Wikidata
View/Edit Human	View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000196220 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030257 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
"Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Wong K, Ren XR, Huang YZ, et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528. S2CID 2458943.
Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388. S2CID 1423222.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Yang Y, Marcello M, Endris V, et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID 16730001.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196220 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030257 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12195014-5] Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.

[entrez-6] "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

SRGAP3

References

Further reading