ST8SIA6

ST8SIA6
Identifiers
Aliases	ST8SIA6, SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139 MGI: 2386797 HomoloGene: 17112 GeneCards: ST8SIA6
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	17,454,330 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	13,794,064 bp[2]
Gene ontology
Molecular function	• transferase activity; • sialyltransferase activity; • transferase activity, transferring glycosyl groups; • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	• integral component of membrane; • Golgi membrane; • Golgi apparatus; • membrane;
Biological process	• glycolipid biosynthetic process; • sialylation; • protein glycosylation; • protein O-linked glycosylation; • glycoprotein metabolic process; • oligosaccharide metabolic process; • ganglioside biosynthetic process; • carbohydrate biosynthetic process; • blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	338596
	241230
	ENSG00000148488
	ENSMUSG00000003418
	P61647
	Q8K4T1
	NM_001004470; NM_001345961
	NM_145838
	NP_001004470; NP_001332890
	NP_665837
	Wikidata
View/Edit Human	View/Edit Mouse

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. [5]

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

References

GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

Avril T, North SJ, Haslam SM, Willison HJ, Crocker PR (2006). "Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression". J. Leukoc. Biol. 80 (4): 787–96. doi:10.1189/jlb.1005559. PMID 16857734. S2CID 7578193.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6". Retrieved 2017-02-02.

ST8SIA6

Function

References

Further reading