STARD3NL

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function.[5] As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

STARD3NL
Identifiers
AliasesSTARD3NL, MENTHO, STARD3 N-terminal like
External IDsOMIM: 611759 MGI: 1923455 HomoloGene: 11501 GeneCards: STARD3NL
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p14.1Start38,178,222 bp[1]
End38,230,671 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

83930

76205

Ensembl

ENSG00000010270

ENSMUSG00000003062

UniProt

O95772

Q9DCI3

RefSeq (mRNA)

NM_024270
NM_001347485

RefSeq (protein)

NP_001334414
NP_077232

Location (UCSC)Chr 7: 38.18 – 38.23 MbChr 13: 19.36 – 19.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.[6]


References

  1. GRCh38: Ensembl release 89: ENSG00000010270 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003062 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: STARD3NL STARD3 N-terminal like".
  6. Alpy F, Tomasetto C (2006). "MLN64 and MENTHO, two mediators of endosomal cholesterol transport". Biochem. Soc. Trans. 34 (Pt 3): 343–5. doi:10.1042/BST0340343. PMID 16709157.

Further reading



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