STAU2

STAU2
Identifiers
Aliases	STAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDs	OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	73,747,708 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	16,520,112 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• double-stranded RNA binding; • GO:0001948 protein binding; • RNA binding;
Cellular component	• cytoplasm; • microtubules; • nucleolus; • endoplasmic reticulum; • membrane; • cell nucleus;
Biological process	• transport;
	Sources:Amigo / QuickGO
Orthologs
	27067
	29819
	ENSG00000040341
	ENSMUSG00000025920
	Q9NUL3
	Q8CJ67
NM_014393; NM_001164380; NM_001164381; NM_001164382; NM_001164383;
	NM_001164384; NM_001164385
	NM_001111272; NM_025303; NM_001347044; NM_001347045
NP_001157852; NP_001157853; NP_001157854; NP_001157855; NP_001157856;
	NP_001157857; NP_055208
	NP_001104742; NP_001333973; NP_001333974; NP_079579
	Wikidata
View/Edit Human	View/Edit Mouse

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[5][6]

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[6]

References

GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
"Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. PMID 12140260.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585778-5] Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.

[entrez-6] "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

STAU2

Function

References

Further reading