SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial is an enzyme that in humans is encoded by the SUPV3L1 gene.[5][6][7]

SUPV3L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUPV3L1, SUV3, Suv3 like RNA helicase
External IDsOMIM: 605122 MGI: 2441711 HomoloGene: 2386 GeneCards: SUPV3L1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q22.1Start69,180,234 bp[1]
End69,209,099 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6832

338359

Ensembl

ENSG00000156502

ENSMUSG00000020079

UniProt

Q8IYB8

Q80YD1

RefSeq (mRNA)

NM_181423
NM_001359806

RefSeq (protein)

NP_852088
NP_001346735

Location (UCSC)Chr 10: 69.18 – 69.21 MbChr 10: 62.43 – 62.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of SUPV3L1 function. A conditional knockout mouse line, called Supv3l1tm1a(EUCOMM)Wtsi[13][14] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][18] Twenty six tests were carried out and three significant phenotypes were reported. All homozygous mutant animals died prior to birth, and therefore none were observed at weaning. The remaining tests were carried out on heterozygous mutant mice and radiography showed female animals had defects in their transverse processes.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000156502 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020079 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dmochowska A, Stankiewicz P, Golik P, Stepien PP, Bocian E, Hansmann I, Bartnik E (Mar 1999). "Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization". Cytogenetics and Cell Genetics. 83 (1–2): 84–5. doi:10.1159/000015135. PMID 9925937. S2CID 903791.
  6. Minczuk M, Mroczek S, Pawlak SD, Stepien PP (October 2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". The FEBS Journal. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273. S2CID 40846992.
  7. "Entrez Gene: SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)".
  8. "Radiography data for Supv3l1". Wellcome Trust Sanger Institute.
  9. "Salmonella infection data for Supv3l1". Wellcome Trust Sanger Institute.
  10. "Citrobacter infection data for Supv3l1". Wellcome Trust Sanger Institute.
  11. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  12. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  13. "International Knockout Mouse Consortium".
  14. "Mouse Genome Informatics".
  15. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  16. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  17. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  18. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q8IYB8 (ATP-dependent RNA helicase SUPV3L1, mitochondria) at the PDBe-KB.


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