SYNPO

Synaptopodin is a protein that in humans is encoded by the SYNPO gene.[5][6][7]

SYNPO
Identifiers
AliasesSYNPO, synaptopodin
External IDsOMIM: 608155 MGI: 1099446 HomoloGene: 5274 GeneCards: SYNPO
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.1Start150,601,080 bp[1]
End150,659,207 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11346

104027

Ensembl

ENSG00000171992

ENSMUSG00000043079

UniProt

Q8N3V7

Q8CC35

RefSeq (mRNA)

NM_001109974
NM_001166208
NM_001166209
NM_007286

NM_001109975
NM_177340

RefSeq (protein)

NP_001103444
NP_001159680
NP_001159681
NP_009217

NP_001103445
NP_796314

Location (UCSC)Chr 5: 150.6 – 150.66 MbChr 18: 60.59 – 60.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM][7]

Interactions

SYNPO has been shown to interact with MAGI1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000171992 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043079 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W (Oct 1997). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes". The Journal of Cell Biology. 139 (1): 193–204. doi:10.1083/jcb.139.1.193. PMC 2139823. PMID 9314539.
  6. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  7. "Entrez Gene: SYNPO synaptopodin".
  8. Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.

Further reading

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