MAGI1

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.[5][6][7]

MAGI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAGI1, AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3, membrane associated guanylate kinase, WW and PDZ domain containing 1, MAGI-1b
External IDsOMIM: 602625 MGI: 1203522 HomoloGene: 31257 GeneCards: MAGI1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p14.1Start65,353,525 bp[1]
End66,038,834 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9223

14924

Ensembl

ENSG00000282956
ENSG00000151276

ENSMUSG00000045095

UniProt

Q96QZ7

Q6RHR9

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 3: 65.35 – 66.04 MbChr 6: 93.68 – 94.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

MAGI1 has been shown to interact with:

References
  1. ENSG00000151276 GRCh38: Ensembl release 89: ENSG00000282956, ENSG00000151276 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000045095 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
  6. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
  7. "Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1".
  8. Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". The Journal of Biological Chemistry. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
  9. Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Molecular and Cellular Neurosciences. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. S2CID 20003277.
  10. Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
  11. Dobrosotskaya IY, James GL (Apr 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochemical and Biophysical Research Communications. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID 10772923.
  12. Ridgway LD, Kim EY, Dryer SE (Jul 2009). "MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface". American Journal of Physiology. Cell Physiology. 297 (1): C55–65. doi:10.1152/ajpcell.00073.2009. PMC 3774261. PMID 19403801.
  13. Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (Nov 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.
  14. Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B (Apr 2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. PMID 11274227.

Further reading
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