Saccharomyces cerevisiae virus L-A

Saccharomyces cerevisiae virus L-A
	ScV-L-A capsid protein structure and homodimer of the gag capsid protein
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Duplornaviricota
Class:	Chrymotiviricetes
Order:	Ghabrivirales
Family:	Totiviridae
Genus:	Totivirus
Species:	Saccharomyces cerevisiae virus L-A
Synonyms
	Saccharomyces cerevisiae virus LA[1]; Saccharomyces cerevisiae virus ScV1[2];

Saccharomyces cerevisiae virus L-A, also called L-A helper virus, is a member of the Totiviridae family of viruses found primarily in Saccharomyces cerevisiae.[3] Its discovery in the 1970s was the main starting point of research on yeast virology.[4] It is a double-stranded RNA virus with no extracellular phase and so is inherited through vertical cytoplasmic transmission.[4] Additionally, in many strains of the yeast, it is found along with another virus called the M virus, known to encode the killer toxin in many S. cerevisiae strains which confers the ability to kill neighboring sensitive cells that do not harbor the virus. It is indeed for this reason the virus is referred to as a helper virus, due to the M genome's dependence on it for its own survival and replication.

Replication cycle of L-A helper and M28 killer viruses in S. cerevisiae.

References

ICTV 5th Report Francki, R. I. B., Fauquet, C. M., Knudson, D. L. & Brown, F. (eds)(1991). Classification and nomenclature of viruses. Fifth report of the International Committee on Taxonomy of Viruses. Archives of Virology Supplementum 2, 452 pp. https://talk.ictvonline.org/ictv/proposals/ICTV%205th%20Report.pdf
"MINUTES OF THE SIXTH MEETING OF THE ICTV, SENDAI, 5th SEPTEMBER 1984" (PDF). International Committee on Taxonomy of Viruses (ICTV). 5 September 1984. Retrieved 10 February 2020.
https://aem.asm.org/content/aem/early/2016/12/05/AEM.02991-16.full.pdf
Schmitt, Manfred J.; Breinig, Frank (March 10, 2006). "Yeast viral killer toxins: lethality and self-protection". Nature Reviews Microbiology. 4 (3): 212–221. doi:10.1038/nrmicro1347. PMID 16489348.

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[1] ICTV 5th Report Francki, R. I. B., Fauquet, C. M., Knudson, D. L. & Brown, F. (eds)(1991). Classification and nomenclature of viruses. Fifth report of the International Committee on Taxonomy of Viruses. Archives of Virology Supplementum 2, 452 pp. https://talk.ictvonline.org/ictv/proposals/ICTV%205th%20Report.pdf

[2] "MINUTES OF THE SIXTH MEETING OF THE ICTV, SENDAI, 5th SEPTEMBER 1984" (PDF). International Committee on Taxonomy of Viruses (ICTV). 5 September 1984. Retrieved 10 February 2020.

[3] ttps://aem.asm.org/content/aem/early/2016/12/05/AEM.02991-16.full.pdf

[auto-4] Schmitt, Manfred J.; Breinig, Frank (March 10, 2006). "Yeast viral killer toxins: lethality and self-protection". Nature Reviews Microbiology. 4 (3): 212–221. doi:10.1038/nrmicro1347. PMID 16489348.