Self/less

Billionaire New Yorker Damian Hale is diagnosed with terminal cancer. He finds a business card directing him to Professor Albright, who informs him about a medical procedure called "shedding", in which one's consciousness is transferred to an artificially grown body. Damian agrees to the procedure and follows Albright's instructions to stage his own public death. Albright transfers him into a new body and prescribes medication to alleviate the vivid hallucinations which he claims are side effects of the procedure.

Damian starts a new life in New Orleans under the assumed name of Edward Kidner and quickly befriends his neighbor Anton. He forgets to take his medicine and has hallucinations of a woman and child. Damian questions Albright, who dismisses it but accidentally mentions details of the hallucinations that Damian had not discussed.

Albright arranges for Damian to take a vacation in Hawaii, but Damian, convinced the hallucinations are a real memory, identifies a landmark he saw in his vision and heads to a farmhouse outside of St. Louis. There, he finds the woman, Madeline, who reacts to him as her apparently deceased husband Mark. Damian plays along as Mark, though shocked to learn that Mark sold himself to Albright to pay for their daughter Anna's life-saving treatment. Damian and Madeline are suddenly attacked by Albright's men, including Anton. Damian fatally wounds Anton and kills his accomplices, then flees with Madeline to collect Anna from school.

At a motel, Damian uses a laptop to research "shedding" and discovers an elderly Dr. Francis Jensen, now deceased, was the pioneer researcher in the field of transhumanism. In a video, Damian notices a tic Jensen shares with Albright, then sees Albright sitting next to Jensen, deducing that Jensen has shed himself into Albright's body.

Damian finds Jensen's wife, Phyllis, in a nursing home, but she is living with Alzheimer's and remembers nothing. Damian lures Jensen to the facility, and Jensen reveals that the pills will eventually eliminate Mark's personality. Without the pills, Damian's consciousness will die, and Mark's will re-emerge.

Jensen escapes when more killers arrive. Damian is almost overpowered, but Madeline wounds the attacker, who proves to be Anton in a new body. Anton reveals that he has shed multiple times. While Damian confiscates Anton's pills, Anton taunts Madeline to ask her "husband" why he can not answer personal questions about their life.

Madeline confronts "Mark" over his lack of knowledge of their personal details, and Damian reveals the entire story. He takes her and Anna to his friend Martin O'Neill and convinces Martin to arrange for Madeline and Anna to flee to the Caribbean. When he and Madeline discover Anna playing with Martin's previously deceased child Tony, Martin admits that he used shedding, and that Albright's men are coming. Damian reveals shedding's secret to Martin, who also believed that the bodies were artificially grown. Damian distracts Jensen's men while Martin flees with the others. Damian again fatally injures Anton, but the other thugs realize that Damian is alone and turn to recapture Madeline and Anna.

Damian stops taking his medicine to experience Mark's memories, which reveal that Jensen has a lab in an abandoned warehouse. Jensen captures him and starts to shed Anton into Mark's body. Damian, remembering that metal interferes with the process, hides a bullet casing in his mouth, destroying Anton's consciousness. Masquerading as Anton, Damian rescues the others. Although Jensen tries to claim that Damian needs him to survive, Martin was able to reverse-engineer the pills and give Damian the formula, allowing Damian to immolate Jensen with a flamethrower. After killing Jensen, he has Martin complete Madeline and Anna's escape to the Caribbean.

Damian visits his estranged daughter Claire but does not reveal his presence inside Mark, simply giving her a letter that reconciles Claire with her father. Damian travels to the Caribbean and stops taking his medicine. The real Mark re-emerges and finds a video message from Damian, thanking him for the time he gave him. Mark reunites with his family.

• Ryan Reynolds as Damian Hale/Mark Bitwell: Reynolds plays both Damian Hale (in Mark Bitwell's body) and Bitwell, the man who has decided to sell his body in order to cover his daughter's medical bills. Bitwell's body is overtaken by Hale's consciousness as a vessel to live through.
• Ben Kingsley as Damian Hale: A wealthy business man who has a terminal illness. He seeks the best care money can buy, a new body.
• Natalie Martinez as Madeline Bitwell: Wife of Mark Bitwell, Madeline is living life convinced her husband has died.
• Matthew Goode as Dr. Jensen/Albright: The creator of the "shedding" process, Dr. Jenson underwent the process in his assistant Albright's body. He is the mastermind of the process, but keeps the secret that instead of engineering human bodies in his laboratory, they pay people considerable amounts of money to donate their bodies as vessels.
• Derek Luke as Anton: First introduced in the movie as Damian's new friend, it is later discovered that Anton works for Albright and was planted in Damian's new life.
• Victor Garber as Martin O'Neill, Damian's close friend
• Jaynee-Lynne Kinchen as Anna Bitwell, Mark's and Madeline's daughter
• Melora Hardin as Judy O'Neill, Martin's wife
• Michelle Dockery as Claire Hale, Damian's estranged daughter
• Sam Page as Carl
• Brendan McCarthy as Anton 2
• Thomas Francis Murphy as Dr. Jensen
• Sandra Ellis Lafferty as Phyllis Jensen
• Emily Tremaine as Mallory
• Teri Wyble as Andrea
• Mariana Vicente as Leah
• Dylan Lowe as Tony O'Neill

Endgame Entertainment and FilmDistrict financed the film, who quickly put the film into development after the two companies saw success with their previous sci-fi film Looper. FilmNation pre-sold the film at Cannes in 2013 and it was the first film to completely sell out at the festival due to universal appeal and the strong pre-sales limited the two financiers' exposure to the budget. FilmDistrict was set to distribute the film in the United States, but the company shut down and was absorbed into Universal's subsidiary Focus Features.

Principal photography began in October 2013 in New Orleans.[4] Scenes were filmed at the Commander's Palace and the Howling Wolf. Antônio Pinto composed the film score. Dudu Aram was credited for additional music, as he had on other scores by Pinto.[5]

The film was originally set to release on February 27, 2015. On July 2, 2014, the film was rescheduled to release on April 17, 2015.[6] However, on November 8, 2014, the studio once again postponed the film for a July 10, 2015 release.[7] The first trailer was released on March 4, 2015.[8][9][10][11] On May 20, 2015, Focus Features relaunched their Gramercy Pictures label for action, horror, and science-fiction movies. Self/less would be one of Gramercy's new releases.[12] However, Gramercy had no credit on the film when it was released.

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