Spin–lattice relaxation in the rotating frame

Spin–lattice relaxation in the rotating frame is the mechanism by which Mxy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a radio frequency (RF) field in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–lattice relaxation time constant in the rotating frame, T. It is named in contrast to T1, the spin-lattice relaxation time.[1]

T MRI is an alternative to conventional T1 and T2 MRI by its use of a long-duration, low-power radio frequency referred to as spin-lock (SL) pulse applied to the magnetization in the transverse plane. The magnetization is effectively spin-locked around an effective B1 field created by the vector sum of the applied B1 and any off-resonant component. The spin-locked magnetization will relax with a time constant T, which is the time it takes for the magnetic resonance signal to reach 37% (1/e) of its initial value, . Hence the relation: , where tSL is the duration of the RF field.

Measurement

T can be quantified (relaxometry) by curve fitting the signal expression above as a function of the duration of the spin-lock pulse while the amplitude of spin-lock pulse (γB1~0.1-few kHz) is fixed. Quantitative T MRI relaxation maps reflect the biochemical composition of tissues.[2]

Imaging

T MRI has been used to image tissues such as cartilage,[3][4] intervertebral discs,[5] brain,[6][7] and heart,[8] as well as certain types of cancers.[9][10]

References

  1. Levitt, Malcolm H. (2016). Spin Dynamics: Basics of Nuclear Magnetic Resonance 2nd Edition. Wiley. ISBN 0470511176.
  2. Borthakur, A; Mellon, E; Niyogi, S; Witschey, W; Kneeland, JB; Reddy, R (Nov 2006). "Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage". NMR in Biomedicine. 19 (7): 781–821. doi:10.1002/nbm.1102. PMC 2896046. PMID 17075961.
  3. Li, X; Benjamin Ma, C; Link, TM; Castillo, DD; Blumenkrantz, G; Lozano, J; Carballido-Gamio, J; Ries, M; Majumdar, S (Jul 2007). "In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI". Osteoarthritis and Cartilage. 15 (7): 789–97. doi:10.1016/j.joca.2007.01.011. PMC 2040334. PMID 17307365.
  4. Witschey, WR; Borthakur, A; Fenty, M; Kneeland, BJ; Lonner, JH; McArdle, EL; Sochor, M; Reddy, R (May 2010). "T1rho MRI quantification of arthroscopically confirmed cartilage degeneration". Magnetic Resonance in Medicine. 63 (5): 1376–82. doi:10.1002/mrm.22272. PMC 2933515. PMID 20432308.
  5. Borthakur, A; Maurer, PM; Fenty, M; Wang, C; Berger, R; Yoder, J; Balderston, RA; Elliott, DM (Dec 1, 2011). "T1ρ magnetic resonance imaging and discography pressure as novel biomarkers for disc degeneration and low back pain". Spine. 36 (25): 2190–6. doi:10.1097/BRS.0b013e31820287bf. PMC 4002043. PMID 21358489.
  6. Borthakur, A; Sochor, M; Davatzikos, C; Trojanowski, JQ; Clark, CM (Jul 15, 2008). "T1rho MRI of Alzheimer's disease". NeuroImage. 41 (4): 1199–205. doi:10.1016/j.neuroimage.2008.03.030. PMC 2473861. PMID 18479942.
  7. Cai, K; Haris, M; Singh, A; Kogan, F; Greenberg, JH; Hariharan, H; Detre, JA; Reddy, R (Jan 22, 2012). "Magnetic resonance imaging of glutamate". Nature Medicine. 18 (2): 302–6. doi:10.1038/nm.2615. PMC 3274604. PMID 22270722.
  8. Witschey, WR; Pilla, JJ; Ferrari, G; Koomalsingh, K; Haris, M; Hinmon, R; Zsido, G; Gorman JH, 3rd; Gorman, RC; Reddy, R (Nov 2010). "Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction". Magnetic Resonance in Medicine. 64 (5): 1453–60. doi:10.1002/mrm.22543. PMC 2965811. PMID 20677236.
  9. Li, LZ; Zhou, R; Xu, HN; Moon, L; Zhong, T; Kim, EJ; Qiao, H; Reddy, R; Leeper, D; Chance, B; Glickson, JD (Apr 21, 2009). "Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential". Proceedings of the National Academy of Sciences of the United States of America. 106 (16): 6608–13. Bibcode:2009PNAS..106.6608L. doi:10.1073/pnas.0901807106. PMC 2672511. PMID 19366661.
  10. Cai, K; Shore, A; Singh, A; Haris, M; Hiraki, T; Waghray, P; Reddy, D; Greenberg, JH; Reddy, R (Feb 2, 2012). "Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research". NMR in Biomedicine. 25 (10): 1125–1132. doi:10.1002/nbm.2780. PMC 3390450. PMID 22302557.


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