TAF4B

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.[4][5][6]

TAF4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAF4B, SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDsOMIM: 601689 MGI: 2152345 HomoloGene: 28266 GeneCards: TAF4B
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q11.2Start26,225,936 bp[1]
End26,391,685 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6875

72504

Ensembl

ENSG00000141384

ENSMUSG00000054321

UniProt

Q92750

G5E8Z2

RefSeq (mRNA)

NM_001293725
NM_005640

NM_001100449
NM_001369357
NM_001369358

RefSeq (protein)

NP_001280654
NP_005631

NP_001093919
NP_001356286
NP_001356287

Location (UCSC)Chr 18: 26.23 – 26.39 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM][6]

Interactions

TAF4B has been shown to interact with RELA.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000141384 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.
  5. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
  6. "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
  7. Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Further reading


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