TCF15

TCF15
Identifiers
Aliases	TCF15, EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15
External IDs	OMIM: 601010 MGI: 104664 HomoloGene: 37943 GeneCards: TCF15
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	610,398 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	152,149,097 bp[2]
Gene ontology
Molecular function	• DNA binding; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus; • RNA polymerase II transcription factor complex;
Biological process	• somitogenesis; • respiratory system process; • regulation of transcription, DNA-templated; • muscle organ morphogenesis; • eating behavior; • neuromuscular process controlling posture; • regulation of transcription from RNA polymerase II promoter; • skeletal system morphogenesis; • muscle organ development; • ear development; • transcription, DNA-templated; • multicellular organism development; • establishment of epithelial cell apical/basal polarity; • regulation of extracellular matrix organization; • post-anal tail morphogenesis; • regulation of gene expression; • mesoderm development; • anterior/posterior pattern specification; • skin development; • paraxial mesoderm development; • mesenchymal to epithelial transition; • transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	6939
	21407
	ENSG00000125878
	ENSMUSG00000068079
	Q12870
	Q60756
	NM_004609
	NM_009328
	NP_004600
	NP_033354
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene. [5]

Function

The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].

References

GRCh38: Ensembl release 89: ENSG00000125878 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000068079 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Transcription factor 15". Retrieved 2017-11-09.

Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). "Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells". J. Biol. Chem. 284 (27): 18184–93. doi:10.1074/jbc.M109.007096. PMC 2709394. PMID 19419955.
Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). "Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake". Circulation. 131 (9): 815–26. doi:10.1161/CIRCULATIONAHA.114.013721. PMID 25561514.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125878 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068079 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Transcription factor 15". Retrieved 2017-11-09.

TCF15

Function

References

Further reading