TCL1A

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[5][6][7]

TCL1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
External IDsOMIM: 186960 MGI: 1097166 HomoloGene: 7565 GeneCards: TCL1A
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.13Start95,709,947 bp[1]
End95,714,196 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8115

21432

Ensembl

ENSG00000100721

ENSMUSG00000041359

UniProt

P56279

P56280

RefSeq (mRNA)

NM_001098725
NM_021966

NM_001289468
NM_009337
NM_001309484
NM_001309485

RefSeq (protein)

NP_001092195
NP_068801
NP_001092195.1
NP_068801.1

NP_001276397
NP_001296413
NP_001296414
NP_033363

Location (UCSC)Chr 14: 95.71 – 95.71 MbChr 12: 105.22 – 105.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TCL1A has been shown to interact with AKT1[8][9][10] and AKT2.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000100721 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041359 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
  6. Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
  7. "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".
  8. Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
  9. Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
  10. French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.