TLE1

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.[5][6][7]

TLE1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTLE1, ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor
External IDsOMIM: 600189 MGI: 104636 HomoloGene: 21058 GeneCards: TLE1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.32Start81,583,683 bp[1]
End81,689,547 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7088

21885

Ensembl

ENSG00000196781

ENSMUSG00000008305

UniProt

Q04724
Q5T3G3

Q62440

RefSeq (mRNA)

NM_001303103
NM_001303104
NM_005077

NM_001285529
NM_001285530
NM_001285531
NM_001285532
NM_011599

RefSeq (protein)

NP_001290032
NP_001290033
NP_005068

NP_001272458
NP_001272459
NP_001272460
NP_001272461
NP_035729

Location (UCSC)Chr 9: 81.58 – 81.69 MbChr 4: 72.12 – 72.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TLE1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000196781 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000008305 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry / FEBS. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
  6. Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
  7. "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)".
  8. Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (Mar 2002). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Molecular and Cellular Biochemistry. 232 (1–2): 163–7. doi:10.1023/A:1014880813692. PMID 12030375. S2CID 8270300.
  9. Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". The Journal of Cell Biology. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
  10. Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. Bibcode:1998PNAS...9511590L. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.
  11. López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P (Jan 2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
  12. Grbavec D, Lo R, Liu Y, Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". European Journal of Biochemistry / FEBS. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. PMID 9874198.
  13. Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.

Further reading

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