TLL1

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.[5][6]

TLL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTLL1, ASD6, TLL, tolloid like 1
External IDsOMIM: 606742 MGI: 106923 HomoloGene: 49202 GeneCards: TLL1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.3Start165,873,237 bp[1]
End166,104,457 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7092

21892

Ensembl

ENSG00000038295

ENSMUSG00000053626

UniProt

O43897

Q62381

RefSeq (mRNA)

NM_001204760
NM_012464

NM_009390

RefSeq (protein)

NP_001191689
NP_036596

NP_033416

Location (UCSC)Chr 4: 165.87 – 166.1 MbChr 8: 64.01 – 64.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000038295 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053626 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
  6. "Entrez Gene: TLL1 tolloid-like 1".

Further reading



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