TMPRSS11D
Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.[4][5][6]
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| Aliases | TMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP | ||||||||||||||||||||||||
| External IDs | OMIM: 605369 MGI: 2385221 HomoloGene: 74519 GeneCards: TMPRSS11D | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 4: 67.82 – 67.88 Mb | n/a | |||||||||||||||||||||||
| PubMed search | [2] | [3] | |||||||||||||||||||||||
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This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.[6]
References
- GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
- Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
- "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D".
Further reading
- Takahashi M, Sano T, Yamaoka K, et al. (2001). "Localization of human airway trypsin-like protease in the airway: an immunohistochemical study". Histochem. Cell Biol. 115 (3): 181–7. doi:10.1007/s004180000243. PMID 11326745. S2CID 25025224.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Miki M, Nakamura Y, Takahashi A, et al. (2003). "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells". J. Med. Invest. 50 (1–2): 95–107. PMID 12630574.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Iwakiri K, Ghazizadeh M, Jin E, et al. (2004). "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris". J. Invest. Dermatol. 122 (4): 937–44. doi:10.1111/j.0022-202X.2004.22415.x. PMID 15102084.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Matsushima R, Takahashi A, Nakaya Y, et al. (2006). "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway". Am. J. Physiol. Lung Cell Mol. Physiol. 290 (2): L385–95. doi:10.1152/ajplung.00098.2005. PMID 16199437.
- Chokki M, Eguchi H, Hamamura I, et al. (2006). "Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells". FEBS J. 272 (24): 6387–99. doi:10.1111/j.1742-4658.2005.05035.x. PMID 16336275. S2CID 34294232.
- Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium". J. Virol. 80 (19): 9896–8. doi:10.1128/JVI.01118-06. PMC 1617224. PMID 16973594.
External links
- Overview of all the structural information available in the PDB for UniProt: Q8VHK8 (Mouse Transmembrane protease serine 11D) at the PDBe-KB.
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