TMUB2

Gene

TMUB2 maps on the human chromosome 17, at locus 17q21.31.[6] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[7] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[8]

Expression

TMUB2 is likely ubiquitously expressed throughout the human body.[9] It has a high expression level that is 2.9 times higher than other human genes.[10][11]

Protein

The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[12] These will likely vary in orthologs.

Homology

Paralogs

TMUB1 is the only paralog of TMUB2.[13][14] These proteins share a 38% identity and 51% similarity.[15]

Orthologs

The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[15]

SpeciesCommon nameAccession numberSequence length (aa)Sequence identitySequence similarity
Pan troglodytesChimpanzeeXP_003953053.1301100%100%
Felis CatusCatXP_003997025.132295%95%
Mus MusculusMouseAAH29841.231985%88%
Alligator MississippiensusAlligatorXP_006271613.130661%71%
Haliaeetus leucocephalusBald EagleXP_01055972830159%70%
Danio rerioZebrafishNP_001005573.129147%60%
Acromyrmex echinatiorAntXP_011049429.135423%42%
Nannochloropsis Gaditana*AlgaeEWM26843.147641%54%
Coccidioides immitis RS*Pathogenic FungusXP_001242306.141838%50%

*Limited Query Coverage

Protein Interactions

In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[16][17][18][19] Other proposed interactions include BCL2L13 (BCL2-like 13),[20] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[20] and UBQLN1 (Ubiquilin-1).[20][21][22]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000034757 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  5. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (June 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  6. "Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2".
  7. UCSC Genome Browser: BLAT Search
  8. NCBI Gene: TMUB2
  9. EST Profile Viewer: Human
  10. Aceview: TMUB2
  11. NCBI GEO Profiles
  12. SDSC Biology Workbench 2.0
  13. GeneCards: TMUB2
  14. NCBI Gene: TMUB1
  15. NCBI BLAST: Basic Local Alignment Search Tool
  16. Danielsen Jannie M R; Sylvestersen Kathrine B; Bekker-Jensen Simon; Szklarczyk Damian; Poulsen Jon W; Horn Heiko; Jensen Lars J; Mailand Niels; Nielsen Michael L (2011). "Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level". Molecular & Cellular Proteomics. 10 (3): M110.003590. doi:10.1074/mcp.M110.003590. PMC 3047152. PMID 21139048.
  17. Wagner S. A.; Beli P.; Weinert B. T.; Nielsen M. L.; Cox J.; Mann M.; Choudhary C. (2011). "A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles". Molecular & Cellular Proteomics. 10 (10): M111.013284. doi:10.1074/mcp.M111.013284. PMC 3205876. PMID 21890473.
  18. Kim Woong; Bennett Eric J.; Huttlin Edward L.; Guo Ailan; Li Jing; Possemato Anthony; Sowa Mathew E.; et al. (2011). "Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome". Molecular Cell. 44 (2): 325–40. doi:10.1016/j.molcel.2011.08.025. PMC 3200427. PMID 21906983.
  19. Povlsen Lou K.; Beli Petra; Wagner Sebastian A.; Poulsen Sara L.; Sylvestersen Kathrine B.; Poulsen Jon W.; Nielsen Michael L.; Bekker-Jensen Simon; Mailand Niels; Choudhary Chunaram (2012). "Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass". Nature Cell Biology. 14 (10): 1089–1098. doi:10.1038/ncb2579. PMID 23000965. S2CID 26442522.
  20. Rolland T, Taşan M, Charloteaux B, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–26. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
  21. STRING: Functional Protein Association Networks
  22. BioGRID Database

Further reading

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