TOMM22

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.[4][5][6]

TOMM22
Identifiers
AliasesTOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22
External IDsOMIM: 607046 MGI: 2450248 HomoloGene: 10638 GeneCards: TOMM22
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,681,957 bp[1]
End38,685,421 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56993

223696

Ensembl

ENSG00000100216

ENSMUSG00000022427

UniProt

Q9NS69

Q9CPQ3

RefSeq (mRNA)

NM_020243

NM_172609

RefSeq (protein)

NP_064628

NP_766197

Location (UCSC)Chr 22: 38.68 – 38.69 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000100216 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol Cell Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
  5. Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane". J Biol Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.
  6. "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)".

Further reading


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